Improved mucosal vaccines

Mucosal Immunity and Vaccines

These mucosal surfaces, while located inside the body, are actually a physical barrier between the outside and the sterile interior cavity of the body known as the “systemic” environment. Critical nutrients, oxygen and other molecules are constantly taken up across these mucosal barriers; however, another important function of the mucous is to keep invading pathogens out [15]. Daily these mucou...

Mucosal Tolerance a Barrier? Perspectives on Mucosal Vaccines: Is

Toward improved influenza vaccines.

Influenza takes a large toll on human health, particularly in the elderly population. The current unadjuvanted trivalent inactivated influenza vaccines (TIVs) are notorious for modest-to-dismal efficacy among elderly individuals. Protection by TIV is limited largely to the 3 or 4 strains chosen for each influenza season. The drifts in circulating strains mean that annual receipt of TIV is recom...

Mucosal delivery of vaccines in domestic animals.

Mucosal vaccination is proving to be one of the greatest challenges in modern vaccine development. Although highly beneficial for achieving protective immunity, the induction of mucosal immunity, especially in the gastro-intestinal tract, still remains a difficult task. As a result, only very few mucosal vaccines are commercially available for domestic animals. Here, we critically review variou...

Recombinant probiotic-Based Vaccines; Attractive vehicles for immunization via mucosal routes

Introduction: The importance of genetically modified microorganisms, including probiotics, now widely have considered as attractive vehicles for mucosal delivery of therapeutic molecules. Previous studies have indicated that mucosal administration of these molecules can effectively trigger humoral along with cellular immune responses. Therefore, development of induction of mucosal immune respon...